The implementation of a lossless data compression module in an advanced orbiting system: Analysis and development

Data compression has been proposed for several flight missions as a means of either reducing on board mass data storage, increasing science data return through a bandwidth constrained channel, reducing TDRSS access time, or easing ground archival mass storage requirement. Several issues arise with the implementation of this technology. These include the requirement of a clean channel, onboard smoothing buffer, onboard processing hardware and on the algorithm itself, the adaptability to scene changes and maybe even versatility to the various mission types. This paper gives an overview of an ongoing effort being performed at Goddard Space Flight Center for implementing a lossless data compression scheme for space flight. We will provide analysis results on several data systems issues, the performance of the selected lossless compression scheme, the status of the hardware processor and current development plan

A kinetic inductance detectors array design for high background conditions at 150 GHz

We present a design for an array of kinetic inductance detectors (KIDs) integrated with phased array antennas for imaging at 150 GHz under high background conditions. The microstrip geometry KID detectors are projected to achieve photon noise limited sensitivity with larger than 100 pW absorbed optical power. Both the microstrip KIDs and the antenna feed network make use of a low-loss amorphous silicon dielectric. A new aspect of the antenna implementation is the use of a NbTiN microstrip feed network to facilitate impedance matching to the 50 Ohm antenna. The array has 256 pixels on a 6-inch wafer and each pixel has two polarizations with two Al KIDs. The KIDs are designed with a half wavelength microstrip transmission line with parallel plate capacitors at the two ends. The resonance frequency range is 400 to 800 MHz. The readout feedline is also implemented in microstrip and has an impedance transformer from 50 Ohm to 9 Ohm at its input and output.Comment: 6 pages, 3 figures, Journal of Low Temperature Physic

The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo

Recent analysis of Rho subfamily GTPases in Drosophila revealed roles for Rac and Cdc42 during axonogenesis. Here, we describe the identification and characterization of the Drosophila counterpart of Trio, a guanine nucleotide exchange factor (GEF) that associates with the receptor phosphatase LAR and regulates GTPase activation in vertebrate cells. Mutants deficient in trio activity display defects in both central and peripheral axon pathways reminiscent of pheno-types observed in embryos deficient in small GTPase function. Double mutant analysis shows that trio interacts with Rac in a dose-sensitive manner but not with Rho. Moreover, reduction of trio activity potentiates the phenotype of mutations in the LAR homolog Dlar, suggesting that these proteins collaborate in orchestrating the cytoskeletal events that underlie normal axonogenesis

3D biofabrication for tubular tissue engineering

The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constructs have the potential to alleviate these concerns with reduced auto-immune response, high anatomical accuracy, long term patency and growth potential. The advent of 3D bio-printing technology has further supplemented the technological toolbox, opening up new biofabrication research opportunities and expanding the therapeutic potential of the field. In this review, we highlight the challenges facing those seeking to create artificial tubular tissue with its associated complex macro and microscopic architecture. Current biofabrication approaches, including 3D printing techniques, are reviewed and future directions suggested

A multi-chroic kinetic inductance detectors array using hierarchical phased array antenna

We present a multi-chroic kinetic inductance detector (KID) pixel design integrated with a broadband hierarchical phased-array antenna. Each low-frequency pixel consists of four high-frequency pixels. Four passbands are designed from 125 to 365 GHz according to the atmospheric windows. The lumped element KIDs are designed with 100 nm Al as the inductor and with Nb parallel plate capacitors using hydrogenated amorphous Si as the dielectric. Due to the broadband coverage, two different types of structures are needed to couple light from microstrip lines to the KIDs. The KIDs designs are optimized for a 10-m-class telescope at a high, dry site.Comment: 6 pages, 4 figures, submitted to Journal of Low Temperature Physic

Prevalence and determinants of dietary supplement and non-prescription medicine use by men and women over 53 years old in Taiwan. Results from a population-based cross-sectional survey

This study investigated the prevalence and determinants of the use of dietary supplements and non-prescription medicines by older adults in Taiwan. Methods:  Data are from the 1999 Survey of Health and Living Status of the Elderly in Taiwan. The survey involved a national random sample of 2360 men and 2080 women, 53 years or older. Results:  Overall, 32.4% of elderly men and 42.7% of elderly women used at least one kind of dietary supplement during the past 12 months. Approximately 16% of elderly men and 19% of elderly women used multivitamin and mineral supplements, 10.5 and 22% used calcium, and 10 and 14% used vitamin E, respectively. Conclusions:  The rates of supplement use are generally lower than those observed in the USA but comparable to that in other industrialised countries. Elderly who are females or who are more highly educated or physically more active are more frequent supplement users.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72609/1/j.1741-6612.2006.00183.x.pd

Maternal Exposure to Occupational Solvents and Childhood Leukemia

Many organic solvents are considered probable carcinogens. We carried out a population-based case–control study including 790 incident cases of childhood acute lymphoblastic leukemia and as many healthy controls, matched on age and sex. Maternal occupational exposure to solvents before and during pregnancy was estimated using the expert method, which involves chemists coding each individual’s job for specific contaminants. Home exposure to solvents was also evaluated. The frequency of exposure to specific agents or mixtures was generally low. Results were generally similar for the period ranging from 2 years before pregnancy up to birth and for the pregnancy period alone. For the former period, the odds ratio (OR), adjusted for maternal age and sex, for any exposure to all solvents together was 1.11 [95% confidence interval (CI), 0.88–1.40]. Increased risks were observed for specific exposures, such as to 1,1,1-trichloroethane (OR = 7.55; 95% CI, 0.92–61.97), toluene (OR = 1.88; 95% CI, 1.01–3.47), and mineral spirits (OR = 1.82; 95% CI, 1.05–3.14). There were stronger indications of moderately increased risks associated with exposure to alkanes (C5–C17; OR = 1.78; 95% CI, 1.11–2.86) and mononuclear aromatic hydrocarbons (OR = 1.64; 95% CI, 1.12–2.41). Risk did not increase with increasing exposure, except for alkanes, where a significant trend (p = 0.04) was observed. Home exposure was not associated with increased risk. Using an elaborate exposure coding method, this study shows that maternal exposure to solvents in the workplace does not seem to play a major role in childhood leukemia

Prolonged and tunable residence time using reversible covalent kinase inhibitors.

Drugs with prolonged on-target residence times often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking. Here we made progress toward this elusive goal by targeting a noncatalytic cysteine in Bruton's tyrosine kinase (BTK) with reversible covalent inhibitors. Using an inverted orientation of the cysteine-reactive cyanoacrylamide electrophile, we identified potent and selective BTK inhibitors that demonstrated biochemical residence times spanning from minutes to 7 d. An inverted cyanoacrylamide with prolonged residence time in vivo remained bound to BTK for more than 18 h after clearance from the circulation. The inverted cyanoacrylamide strategy was further used to discover fibroblast growth factor receptor (FGFR) kinase inhibitors with residence times of several days, demonstrating the generalizability of the approach. Targeting of noncatalytic cysteines with inverted cyanoacrylamides may serve as a broadly applicable platform that facilitates 'residence time by design', the ability to modulate and improve the duration of target engagement in vivo

Star Formation in Self-Gravitating Disks in Active Galactic Nuclei. I. Metallicity Gradients in Broad-Line Regions

It has been suggested that the high metallicity generally observed in active galactic nuclei (AGNs) and quasars originates from ongoing star formation in the self-gravitating part of accretion disks around supermassive black holes (SMBHs). We designate this region as the star-forming (SF) disk, in which metals are produced from supernova explosions (SNexp) while at the same time inflows are driven by SNexp-excited turbulent viscosity to accrete onto the SMBHs. In this paper, an equation of metallicity governed by SNexp and radial advection is established to describe the metal distribution and evolution in the SF disk. We find that the metal abundance is enriched at different rates at different positions in the disk, and that a metallicity gradient is set up that evolves for steady-state AGNs. Metallicity as an integrated physical parameter can be used as a probe of the SF disk age during one episode of SMBH activity. In the SF disk, evaporation of molecular clouds heated by SNexp blast waves unavoidably forms hot gas. This heating is eventually balanced by the cooling of the hot gas, but we show that the hot gas will escape from the SF disk before being cooled, and diffuse into the broad-line regions (BLRs) forming with a typical rate of ~1 M☉ yr–1. The diffusion of hot gas from an SF disk depends on ongoing star formation, leading to the metallicity gradients in BLR observed in AGNs. We discuss this and other observable consequences of this scenario

Star formation in self-gravitating disks in active galactic nuclei. I. Metallicity gradients in broad line regions

It has been suggested that the high metallicity generally observed in active galactic nuclei (AGNs) and quasars originates from ongoing star formation in the self-gravitating part of accretion disks around the supermassive black holes. We designate this region as the star forming (SF) disk, in which metals are produced from supernova explosions (SNexp) while at the same time inflows are driven by SNexp-excited turbulent viscosity to accrete onto the SMBHs. In this paper, an equation of metallicity governed by SNexp and radial advection is established to describe the metal distribution and evolution in the SF disk. We find that the metal abundance is enriched at different rates at different positions in the disk, and that a metallicity gradient is set up that evolves for steady-state AGNs. Metallicity as an integrated physical parameter can be used as a probe of the SF disk age during one episode of SMBH activity. In the SF disk, evaporation of molecular clouds heated by SNexp blast waves unavoidably forms hot gas. This heating is eventually balanced by the cooling of the hot gas, but we show that the hot gas will escape from the SF disk before being cooled, and diffuse into the BLRs forming with a typical rate of \sim 1\sunmyr. The diffusion of hot gas from a SF disk depends on ongoing star formation, leading to the metallicity gradients in BLR observed in AGNs. We discuss this and other observable consequences of this scenario.Comment: 11 pages, 5 Figures, ApJ, Vol. 737, in pres